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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

This timeline matches the typical drug development pathway: Phase 3 completion FDA submission 6-12 month review approval commercial manufacturing ramp-up pharmacy distribution

UnitedHealth Group would need to separate OptumRx from Optum Specialty Pharmacy and associated dispensing entities

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